Rbm38 in cancer: role and mechanism

Author: bkyc

August undefined, 2024

http://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.032 WebSequencing dataset GSE70665 was then used to analyze the role of DEGs in the development of OLP to oral squamous cell carcinoma (OSCC). ... Kong X, Wang D, Sun W, et al. Small proline-rich protein 2A and 2D are regulated by the RBM38-p73 axis and associated with p73-dependent suppression of chronic inflammation. Cancers (Basel). 2024;13 ...

RBM38 RNA binding motif protein 38 [ (human)] - National Center …

WebThe RNA-binding protein Rbm38 is dispensable during ... Somatic mutational landscape of splicing factor genes and their functional consequences across 33 Cancer types. Cell Rep. 2024; 23: 282 ... a subset of patients with end-stage heart failure may represent a starting point for future studies to elucidate their role and mechanism in the ... WebJul 8, 2024 · Here, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies … the key by wayne dobson

RBM38 plays a tumor-suppressor role via stabilizing the p53

WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, … WebMar 9, 2024 · Results report that RBM38 mediates direct inhibition of c-Myc expression, which in turn suppresses RBM38 expression. Thus, it can be concluded that RBM38 and c … WebAutophagy plays a complex role in tumor cells; studies have shown that autophagy can both inhibit cancer onset and promote advanced tumor growth. 4 Increasing evidence shows that cancer cells are more dependent on autophagy than normal cells, and this dependence may be further strengthened during the treatment process. 5 An increasing number of research … the key by madison

Serotonin acts through YAP to promote cell proliferation: mechanism …

RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1 ...

WebRBM38 in cancer: role and mechanism Author: Cheng Zou, Ying Wan, Lingjing He, Jin Hai Zheng, Yang Mei, Junfeng Shi, Min Zhang, Zhiqiang Dong, Dingxiao Zhang Source: Cellular … WebOct 1, 2024 · Despite their abundance and several large-scale studies showing their contribution to the evolution of gene-regulatory networks, their role in physiology and various diseases, including cancer, remains relatively rare [2,7,8]. The tumor suppressor p53 is the most commonly mutated gene in human cancers. the key by tems lyricsWebRecent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or the key cafe ipswich

"WebApr 7, 2024 · This mechanism is strongly related to inactivation of Rb1 by the HPV E7 protein [19,20]. Not all mechanisms associated with p16 expression are known in cancers. Although many studies have reported on the prognostic role of the decreased or increased p16 expression, the results are often conflicting . " - Rbm38 in cancer: role and mechanism

Rbm38 in cancer: role and mechanism

The role of c-Myc-RBM38 loop in the growth suppression in breast …

WebSep 3, 2024 · Deactivation of RBM38 could disrupt p53-mdm2 loop function and promote HCC, but its role and molecular mechanism remain scanty and contradictory. In the … WebPeptidyl–prolyl isomerases (PPIase) facilitate the cis–trans interconversion of the peptidyl–prolyl bond and in such way affect protein folding. Pin1 is a PPIase, which specifically recognizes phosphorylated S/T-P bonds. The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARα) at position Ser 77.In the …

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WebDec 15, 2014 · However, the biological function of Rbm38 and the role of the p53-R... SignificanceRNA-binding motif protein 38 ... altered expression of Rbm38 is found in … WebJul 24, 2024 · This mechanism is similar to eIF2 alpha phosphorylation ... (Gerlitz et al., 2002; Tinton et al., 2005) or cleavage of scaffolding need to increase our understanding on the role of sequences and ... RNA unique RNA binding domain indicated as a K-homology domain binding motif 38 (RBM38) is an RBP that is ...

WebSep 29, 2011 · This review highlights a decade of investigations into the role of CD38 in CLL. An association between CD38 expression by CLL cells and a more aggressive clinical behavior was first reported in 1999 4 and confirmed by several subsequent studies. 8-12 Consequently, determination of the percentage of CD38-expressing cells within a clone … WebApr 11, 2024 · Background Hypoxia-inducible factors (HIFs) are the most essential endogenous transcription factors in the hypoxic microenvironment and regulate multiple genes involved in the proliferation, migration, invasion, and EMT of hepatocellular carcinoma (HCC) cells. However, the regulatory mechanism of HIFs in driving HCC progression …

WebCROSS-REFERENCE TO RELATED APPLICATIONS. This application is a Continuation of U.S. patent application Ser. No. 16/649,732, filed Mar. 23, 2024, which is a national stage filing u WebApr 12, 2024 · An inducible mouse model of colonic cancer was founded using AOM + DSS treatment to investigate the roles of exogenous 5-HT in the carcinogenesis of colon cancer. After 90 days of treatment with 10 mg/kg 5-HT (Fig. 5 A), the tumour number and volume in the mice’s intestinal mucosa were 11.60 ± 1.52 and 14.35 ± 2.72 mm 3 , respectively.

WebSep 3, 2024 · Methods: In the present study, we investigated the role and molecular mechanism of misregulation in the p53-mdm2 loop function by RBM38 in HCC. First we …

WebSep 1, 2012 · Abstract. The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and is a critical downstream target of the tumor suppressor pRB. The pRB/E2F pathway is defective in most human tumors, resulting in deregulated E2F activity that induces uncontrolled cell proliferation, a hallmark of tumor … the key by temsWebA RBM38 suppresses cell proliferation via destabilizing oncogene MYC and stabilizing TS PTEN through AREs in their 3 ... role and mechanism Cancer is the second leading cause of death globally. the key care managementWebNov 19, 2024 · Breast cancer (BC) is a common type of malignant tumor that is frequently accompanied by drug resistance, which is a significant challenge in the treatment of BC. Adriamycin (ADM) is a commonly used drug for the treatment of BC. The aim of the present study was to demonstrate the association between RNA binding motif protein 38 … the key cafeWebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, 12, 359–369. ... A schematic model of the mechanism by which Rbm38 suppresses the transcription defect caused by splicing deficiency. the key by whitley strieberWebApr 12, 2024 · Fig. 1: USP1 is an important regulator of Hippo signaling activity, and its expression is elevated in human hepatocellular carcinoma. A The flowchart shows the siRNA screening procedure for ... the key centre irvineWebInternational Journal of Molecular Sciences, an international, peer-reviewed Open Access journal. the key by simon toyneWebDec 1, 2024 · PDF Background: Misregulation of the p53-mdm2 loop function is a major mechanism to promote hepatocellular carcinoma (HCC). RBM38, a member of the... … the key cbpe