Hoat3
Nettet27. okt. 2024 · Previously explored DDDI simulations between rivaroxaban and amiodarone in renal impairment were firstly recapitulated by integrating hOAT3 … NettetIn addition to the transport of p-aminohippurate and estrone sulfate, that of antifolates and antivirals was inhibited by caffeic acid. These findings show that caffeic acid has …
Hoat3
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Nettet1. okt. 2005 · To determine the affinity of cephalosporins for hOAT1 and hOAT3, we examined the inhibitory effects of these drugs on the uptake of p-[14 C]aminohippurate … Nettet15. feb. 2007 · First, we investigated the time-dependent uptake of adefovir, cidofovir and tenofovir by HEK-pBK and HEK-hOAT3. As shown in Fig. 1, the expression of hOAT3 …
NettetBK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC). To … Nettet1. feb. 2012 · Both hOAT1 and hOAT3 markedly stimulated the uptake of kynurenic acid into oocytes, and the K m values of the transport were calculated to be 5.06 μM and 4.86 μM, respectively. The transport efficiencies of kynurenic acid by hOAT1 and hOAT3 were comparable to those of p-aminohippurate and estrone
NettetToxins 2010, 2 2056 1. Specific Renal Vulnerability A variety of pathogenic mechanisms play a role in drug-induced nephrotoxicity, including hemodynamic changes, glomerular disease, interstitial nephritis, direct cytotoxicity which may result Nettet5. nov. 2012 · Transporter-mediated drug-drug interactions in the kidney dramatically influence the pharmacokinetics and other clinical effects of drugs. Human organic anion …
Nettet2. nov. 2013 · PCS is a substrate for hOAT1 and hOAT3, and hOAT1 and hOAT3 appear to play a physiological role as a high-capacity PCS transporter. Since hOATs are expressed not only in the kidneys, but also in blood vessels and osteoblasts, etc., these findings are of great significance in terms of elucidating the renal clearance, tissue …
Nettet1. mai 2001 · A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. The deduced amino acid sequence of hOAT3 showed 36 to 51% identity to … map california earthquake todayNettet1. nov. 2004 · Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic acid methotrexate, … map calhoun county msNettetOAT3 is involved in the transport and excretion of organic ions some of which are drugs (e.g., penicillin G (benzylpenicillin), methotrexate (MTX), indomethacin (an NSAID ), … kraft heinz competition analysisNettetIn this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated. Madin–Darby canine kidney (MDCK)-hOAT1, HEK293-hOAT3 and … kraft heinz company zoominfoNettet17. sep. 2013 · Pemetrexed and methotrexate transport by hOAT3 was saturated at high concentrations with apparent Km values 28.2 µM and 76.6 µM, respectively. In addition, intrinsic activity (Vmax/Km) of ... kraft heinz company wikiNettet13. jun. 2024 · Evidence was further provided that sgk1 regulation of hOAT3 activity was mediated by ubiquitin ligase Nedd4–2, an enzyme previously shown to have an inhibitory effect on hOAT3. It was shown that sgk1 phosphorylated Nedd4–2, weakened the association between Nedd4–2 and hOAT3, and decreased hOAT3 ubiquitination. map california county linesNettet1. nov. 2005 · We examined the substrate specificity of human organic anion transporter (hOAT) 1 and hOAT3 for various cephalosporin antibiotics, cephaloridine, cefdinir, … map california earthquake