Cisplatin prodrug
WebPurpose: Cisplatin plus gemcitabine (GEM) is a standard regimen for the first-line treatment of advanced non-small cell lung cancer. The aim of this study was to prepare biocompatible and biodegradable polymeric prodrugs and construct nanoparticles (NPs) with layer-by-layer (LbL) technique. Methods: Platinum (Pt) (IV) complex with a carboxyl ... WebSep 18, 2024 · National Center for Biotechnology Information
Cisplatin prodrug
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WebCisplatin, as the traditional chemotherapeutic agent against ovarian cancer, retains several limitations, such as drug resist... CuS Nanoparticles-Loaded and Cisplatin Prodrug … Web(20) Therefore, Pt (IV)-based cisplatin prodrug (DSCP) is applied to make use of the increasing GSH in cancer cells. In normal tissues and cells, Pt (IV) in DSCP is stable and shows less cytotoxicity under low GSH levels.
WebApr 23, 2024 · Abstract. Drug resistance has always been a huge challenge that should be urgently conquered to improve the efficacy of anticancer drugs. Herein, a synergistic Pt … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
WebFeb 28, 2024 · This review summarizes the recent advances in the synthesis of both platinum(II) and prodrugs platinum(IV) complexes for cisplatin-resistant cancer cell lines, whose therapeutic treatment still represents a great challenge. This can be correlated to the lack of selectivity toward the desired target and, therefore, the systemic side effects that ... Webcontaining both cisplatin prodrug and REV1/REV3L-specific siRNAs was further investigated in vitro and in vivo. Quantitative real-time PCR results showed that the NPs exhibited a significant and sustained suppression of both genes in tumors for up to 3 d after a single dose. Administering these NPs revealed a synergistic ef-
WebThe topoisomerase II inhibitor Etp inhibits DNA production by affecting the premitotic phase of cell division. 11 Poor solubility and chemical instability are major limits to its clinical …
WebJan 9, 2014 · UGA researchers combined cisplatin with aspirin in a new single prodrug formulation they call Platin-A, which prevents these negative side effects by reducing inflammation. They reported their findings recently in Angewandte Chemie, a journal published by the German Chemical Society. “We know that inflammation plays a major … prattsburgh market place groceryWebPurpose: Prodrug technology-based combination drug therapy has been exploited as a promising treatment strategy to achieve synergistic lung cancer therapy, reduce drug dose, and decrease side effects. In the present study, we synthesized a pH and glutathione (GSH) sensitive prodrug, cisplatin (CIS) and doxorubicin (DOX) conjugates (CIS-DOXp). prattsburgh ny mapWebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. prattsburgh rural cemetery nyWebThe topoisomerase II inhibitor Etp inhibits DNA production by affecting the premitotic phase of cell division. 11 Poor solubility and chemical instability are major limits to its clinical application. 12 A prodrug is a kind of compound containing a parent drug that carries out biotransformation in vivo through chemical or enzymatic cleavage ... prattsburgh ny land for saleWebFeb 28, 2024 · This review summarizes the recent advances in the synthesis of both platinum(II) and prodrugs platinum(IV) complexes for cisplatin-resistant cancer cell … prattsburgh ny weather camWebThis combination therapeutic approach can sensitize cancer cells to chemotherapeutics and shows superior tumor inhibition compared with monochemotherapy. Abstract Cisplatin … prattsburgh ny weather radarWebAug 1, 2015 · To address these issues we have designed a novel prodrug of cisplatin, BTP-114. On infusion into the blood a maleimide group on BTP-114 covalently attaches to serum albumin. This prolongs the circulation of BTP-114 in plasma and alters the biodistribution of the compound. Importantly the dose of platinum can be increased and … prattsburgh ny wind farm